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日本京都大学启动iPS细胞药物治疗ALS的临床试验

2019-03-28 09:22:46     来源:中新网     责任编辑:刘欣

  中新网3月28日电 据日本放送协会(NHK)报道,日前,日本京都大学等组成的研究小组宣布,通过使用iPS细胞,发现有一种药物或许可以遏制肌萎缩性脊髓侧索硬化症(ALS)。目前,该研究小组已经开始进行临床试验。

资料图:iPS细胞。

资料图:iPS细胞。

  据悉,ALS是一种会导致全身肌肉萎缩、且目前无法根治的疾病。

  日本京都大学iPS细胞研究所教授井上治久等率领的研究小组宣布,通过使用由ALS患者的细胞转化而成的iPS细胞,发现有一种药物或许可以遏制该疾病的症状。为了让这一疗法早日通过政府审批,该研究小组已经从本月18日起启动了临床试验。

  临床试验所用的药物名为“Bosutinib”,是一种治疗慢性髓性白血病的药物。根据试验计划,研究小组将在京都大学附属医院等4家医疗机构,募集最多24名患者参与试验。这些患者将先连续12周服用该药物,以确认药物的安全性。

  井上教授表示:“目前通过审批的药物中,没有任何一种可以从根本上遏制病症,我们希望能向前迈进一步。”

  目前,日本国内约有9000名ALS患者,医学界尚未找到可以治本的疗法。研究小组表示,这是日本国内继庆应大学之后,第2例使用iPS细胞研发该疾病治疗药物的尝试,也是全球第3例。

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